Surgical management of pancreatic neuroendocrine neoplasms

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PANCREATIC NEUROENDOCRINE NEOPLASMS (pNENs)

Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare lesions that have been increasing in incidence over the past few decades largely because of the diagnosis of pancreatic incidentalomas on cross-sectional imaging. Most of these tumors are nonfunctioning presenting with symptoms secondary to mass effect, metastatic disease or as incidental findings. Diagnostic workup aims to assess ...

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Surgical Management of Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors (pancNETs) are uncommon tumors with an estimated incidence of 1 to 1.5 per 100,000 and a prevalence of 35 per 100,000 in the United States. They originate from the embryonic endodermal cells that give rise to the islets of Langerhans. These cells are specialized cells that produce, store, and secrete peptides and biogenic amines and were formerly known as the am...

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Pancreatic carcinoids (serotonin-producing pancreatic neuroendocrine neoplasms)

INTRODUCTION Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secret...

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Outcome of surgery for pancreatic neuroendocrine neoplasms.

BACKGROUND The incidence of pancreatic neuroendocrine neoplasms (pNEN) is increasing. This study aimed to evaluate predictors of overall survival and the indication for surgery. METHODS Data collected between October 2001 and December 2012 were analysed. Histological grading and staging was based on the classifications of the World Health Organization, the International Union Against Cancer a...

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The surgical spectrum of pulmonary neuroendocrine neoplasms.

OBJECTIVES The purpose of this study is to review our experience with the spectrum of neuroendocrine neoplasms of the lung with emphasis on the histopathologic classification and surgical therapy of each class of neoplasm. DESIGN This retrospective review covers the entire spectrum of neuroendocrine neoplasms of the lung over an 11-year period (January 1985 to December 1995) in a university h...

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ژورنال

عنوان ژورنال: Annals of Saudi Medicine

سال: 2014

ISSN: 0256-4947,0975-4466

DOI: 10.5144/0256-4947.2014.1